Anti-MHC Class I
MHC Class I molecules play a pivotal role in the immune system, presenting peptides from the endoplasmic reticulum. They are composed of a heavy alpha chain and beta-2 microglobulin and are expressed on most cells, excluding some like fibroblasts and neurons. Their primary function is to present cytosolic protein fragments to CD8+ T cells, modulating the adaptive immune response and this process involve the ubiquitin-proteasome system, peptide transporters, and chaperone proteins. Defects in this system can facilitate tumor immune evasion and the polymorphisms within MHC Class I genes impact their peptide binding specificity, crucial for transplantation typing.
| Intended Use | IVD for Both |
|---|---|
| Antibody Type | Monoclonal |
| Clone | F-3 |
| Localisation | Nucleus |
| Source | Mouse |
| Isotype | IgG1, kappa |
| Tissue Type/Cancer Type | Prostate and Liver tissues |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual, 50 tests – NanoVIP® |
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