Anti-IDH1 R132H
IDH1 (Isocitrate Dehydrogenase 1), a cytosolic enzyme in the Krebs citric acid cycle, exhibits the R132H mutation often seen in astrocytomas and oligodendroglial tumors, correlating with improved patient outcomes. This mutation causes abnormal IDH1 activity and the production of oncometabolite 2-hydroxyglutarate, promoting glioma formation and progression. IDH1 R132H aids in diagnosing different glioma grades and serves as a prognostic marker for gliomas and secondary glioblastoma multiforme, contributing to refining the molecular classification of adult gliomas when combined with other markers.
| Intended Use | IVD for Both |
|---|---|
| Antibody Type | Monoclonal |
| Clone | MRQ-67 |
| Localisation | Cyt |
| Source | Rabbit |
| Isotype | IgG1 |
| Tissue Type/Cancer Type | Acute Myeloid leukemia tissue |
| Pack | 6ml Manual RTU, 100 Tests Automation i6000, 50 Tests Automation NanoVIP, 50 Tests Automation Xmatrx, 160 Tests Automation Xmatrx, 1ml Manual Conc, 0.5ml Manual Conc, 5 Slides Xmatrx, 5 Slides Manual |
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