Anti-CD223

Datasheet | SDS

CD223, also referred to as LAG-3, is a 70-kDa surface glycoprotein belonging to the Ig superfamily and sharing homology with CD4. It exhibits a greater affinity for binding to MHC class II than CD4 and primarily functions in the inhibition of T cell activation and homeostatic proliferation. CD223 is expressed on activated T cells, including regulatory T cells and NK cells, with higher levels seen in CD8+ T cells than CD4+ T cells. Co-expression of CD223 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells). CD223’s role as a high-affinity MHC class II ligand and its association with Tr1 cells highlights its significance in cancer diagnosis and immunotherapeutic approaches.