Anti-Histone H3 [PHH3/471R]
![Anti-Histone H3 [PHH3/471R]](https://biogenex.seosmo.click/wp-content/uploads/2021/10/HISTONEH3_ANB88.jpg)
Histone H3 (also known as Histone H3.1t, H3/t, H3t, or H3/g) encoded by the gene HIST3H3/H3Ft, is one of the nuclear proteins responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. They play a crucial role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Acetylation and or methylation of Histone H3 occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression. Hence, Histone H3 has been linked to various types of cancer as a biomarker through the aberrant expression of histone deacetylase (HDAC) enzymes and changes to chromatins.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | PHH3/471R |
| Source | Rabbit |
| Tissue Type | Tonsil Tissue |
| Pack | 6 mL (RTU), 100 Tests – Automation – i6000, 1 mL(Conc.), 0.5 mL (Conc.), 50 tests – Xmatrx Elite, 50 tests – NanoVIP, 160 tests – Xmatrx Elite, 5 slides – Manual, 5 slides – Xmatrx |
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