Anti-MHC Class I

DatasheetSDS

MHC Class I molecules play a pivotal role in the immune system, presenting peptides from the endoplasmic reticulum. They are composed of a heavy alpha chain and beta-2 microglobulin and are expressed on most cells, excluding some like fibroblasts and neurons. Their primary function is to present cytosolic protein fragments to CD8+ T cells, modulating the adaptive immune response and this process involve the ubiquitin-proteasome system, peptide transporters, and chaperone proteins. Defects in this system can facilitate tumor immune evasion and the polymorphisms within MHC Class I genes impact their peptide binding specificity, crucial for transplantation typing.