Anti-MRP3
MRP3 (Multidrug Resistance-Associated Protein 3) belongs to the MRP subfamily within the ATP-binding cassette (ABC) transporter superfamily, plays a pivotal role in the efflux of organic anions, such as bile acids and anti-cancer drugs, from the liver and small intestine into the bloodstream. This function contributes to the development of multi-drug resistance. MRP3 is expressed in various organs, including the liver, gallbladder, small intestine, colon, kidney, and adrenal gland. Elevated levels of MRP3 expression have been observed in liver diseases and specific types of cancer, including hepatocellular carcinoma, ovarian cancer, and acute lymphoblastic leukaemia. Overexpression of MRP3 has been identified as a prognostic factor in acute lymphoblastic leukaemia (ALL) and adult acute myeloid leukaemia (AML).
| Intended Use | IVD |
|---|---|
| Clone | ABCC3/2971 |
| Localisation | Mem & Cyt |
| Antibody Type | Monoclonal |
| Tissue Type/Cancer Type | Pancreas tissues |
| Source | Mouse |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
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