Anti-PTEN, Clone 6H2.1
Phosphatase and tensin homologue deleted on chromosome TEN (at 10q23) (PTEN) is a tumor suppressor and a member in the PI3K/PTEN/Akt pathway. PTEN gene encodes a 403 amino acid cytosolic lipid phosphatase that negatively regulates AKT activity by dephosphorylating phosphatidylinositol 3,4,5-trisphosphate (PIP3). The defects of PTEN have been implicated in human cancers from breast, prostate, thyroid, skin, endometrium, head and neck, and brain. Up to 50-60 percent of advanced prostate cancers show abnormal PTEN gene expression or loss of protein expression.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Source | Mouse |
| Clone | 6H2.1 |
| Tissue Type | Breast carcinoma tissue |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual, 50 tests – NanoVIP® |
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