Anti–SLUG
Slug, a 29 kDa transcriptional repressor belonging to the Snail family, exhibits induced expression in response to FGF, BMP, and TGF-β. Functioning as a negative regulator of gene expression, it binds to E-cadherin and integrin promoters, suppressing transcription and influencing cell adhesion and the embryonic epithelial-mesenchymal transition, a mechanism exploited by invasive cancer cells. Additionally, Slug protects damaged cells from apoptosis by suppressing of the proapoptotic Puma protein via histone deacetylase-1. Controlling the activity of multiple genes like TP53, BRCA2, PUM, and CDH1, Slug plays a crucial role in neural crest development. In breast, esophageal, and colorectal carcinomas, Slug’s presence often signifies a poor prognosis for survival.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | A-7 |
| Source | Mouse |
| Tissue Type/Cancer Type | Breast tissue |
| Pack | 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
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